منابع مشابه
EZH2 takes the stage when BRCA1 loses
www.landesbioscience.com Cell Cycle 3575 BRCA1 is a hereditary breast cancer susceptibility gene. BRCA1 germ-line mutation carriers have greatly increased lifetime risks for development of breast cancer. Strikingly, BRCA1 mutations are synonymous with incidence of basal-like breast cancer, with characteristic expression of basal cell markers, including cytokeratins (CKs) 5/6 and CK17. This uniq...
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Germline breast cancer 1 (BRCA1) variants are associated with a high risk of breast and ovarian cancers. Many BRCA1-mediated cancers are initially responsive to platinum-based therapy; however, resistance commonly develops. The BRCA1185delAG mutation is common in the Ashkenazi Jewish population and has been thought to result in loss of function due to the introduction of a stop codon in the 5' ...
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The deployment of virtual characters in intermedia performance drives divergent agendas of this research group. From the perspective of performance studies, we examine the effect of computer-based characters as actors and believe explorations of mediated agency can open up new forms of engagement for live productions. From the visualisation point of view, we are interested in how abstraction an...
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Rapamycin, a FDA-approved pharmaceutical, has received significant attention as a possible anti-aging agent since the groundbreaking discovery in 2009 that rapamycin treatment significantly extends the lifespan of mice [1]. Excitingly, rapamycin not only extends lifespan, it also extends healthspan in rodent models, preventing and delaying the onset of age-related diseases, including cancer and...
متن کاملWhen fieldwork takes a detour.
This study explored the experience of occupational therapists who encountered counterproductive events during their fieldwork training. Interviews were conducted to gather information regarding the participant's perception of factors that contributed to a negative fieldwork experience. The results were divided into major categories: (1) the role of the supervisor, (2) poor supervisory character...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.26785